Listar Artículos WOS por autor "Molina, Claudio [Chile. Universidad Mayor]"
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Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren's syndrome patients
Aguilera, Sergio [Chile. Clínica INDISA]; Brockhausen, Inka [Canadá. Queens University]; Molina, Claudio [Chile. Universidad Mayor]; González, Sergio [Chile. Universidad Mayor] (CIENCIAS, 2012)OBJECTIVES: To determine the expression and enzymatic activities of sulphotransferases involved in mucin hyposulphation in labial salivary glands (LSGs) from SS patients and to correlate sulphotransferase activity with ... -
Disruption of Tight Junction Structure in Salivary Glands From Sjogren's Syndrome Patients Is Linked to Proinflammatory Cytokine Exposure
Aguilera, Sergio [Chile. Clínica INDISA]; Alliende, Cecilia [Universidad de Chile]; Kwon, Yoon-Jeoung [Universidad de Chile]; Albornoz, Amelina [Universidad de Chile]; Molina, Claudio [Chile. Universidad Mayor]; Urzua,Ulises [Universidad de Chile] (CIENCIAS, 2010)OBJECTIVE: Disorganization of acinar cell apical microvilli and the presence of stromal collagen in the acinar lumen suggest that the labial salivary gland (LSG) barrier function is impaired in patients with Sjögren's ... -
Gene expression and chromosomal location for susceptibility to Sjogren's syndrome
Anaya, Juan-Manuel [Colombia.Universidad del Rosario]; Aguilera, Sergio [Chile. Universidad Andrés Bello]; Úrzua, Ulises [Universidad de Chile]; Munroe, David [Estados Unidos. National Institutes of Health NIH]; Molina, Claudio [Chile. Universidad Mayor] (CIENCIAS, 2009)Primary Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease affecting mainly the exocrine glands. Its physio-pathology is poorly understood and most of the knowledge has been related to the inflammatory ... -
Increased acinar damage of salivary glands of patients with Sjogren's syndrome is paralleled by simultaneous imbalance of matrix metalloproteinase 3/tissue inhibitor of metalloproteinases 1 and matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 1 ratios
Kwon,Yoon-Jeoung [Universidad de Chile]; Alliende, Cecilia [Universidad de Chile]; Leyton,Lisette [Universidad de Chile]; Aguilera, Sergio [Chile. Universidad Andrés Bello]; Molina, Claudio [Chile. Universidad Mayor]; Labra, Cecilia [Universidad de Chile] (CIENCIAS, 2005)OBJECTIVE: Previous findings in labial salivary glands (LSGs) from patients with Sjögren's syndrome (SS) suggest that increased activity and expression of matrix metalloproteinase 9 (MMP-9) and MMP-3 trigger the destruction ... -
Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary glands from patients with Sjogren's syndrome
Pérez,Paola [Universidad de Chile]; Aguilera, Sergio [Chile. Universidad Andrés Bello]; Molina, Claudio [Chile. Universidad Mayor]; Leyton, Lisette [Universidad de Chile]; Alliende, Cecilia [Universidad de Chile]; Leyton,Cecilia [Universidad de Chile] (CIENCIAS, 2006)OBJECTIVE: To investigate remodeling of the basal lamina of labial salivary glands (LSGs) from patients with Sjögren's syndrome (SS) by analyzing the expression of specific components that participate in its assembly and ... -
Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjogren's syndrome?
Aguilera, Sergio [Chile. Clínica INDISA]; Veerman, Enno [Holanda. Academic Centre for Dentistry Amsterdam]; González, Sergio [Chile. Universidad Mayor]; Molina, Claudio [Chile. Universidad Mayor] (CIENCIAS, 2015)Objectives. A hallmark characteristic of SS patients is the ectopic presence of the mucins MUC5B and MUC7 in the extracellular matrix of salivary glands that have lost apical-basolateral acinar-cell polarity. This study ...