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Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding
(Nature Publishing Group, 2017)
Numerous epidemiological studies have shown a significantly higher risk for development of Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular mechanism responsible for this association ...
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
(Rockefeller University Press, 2017)
Although a large proportion of patients with type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown. Here, we show that pancreatic IAPP ...
Factores de riesgo asociados al desarrollo de hypertensión arterial en Chile
(Sociedad Médica de Santiago, 2017)
Background: High blood pressure is one of the major risk factors for the development of cardiovascular disease, affecting 27% of the Chilean population in 2010. Aim: To determine the risk factors associated with the ...
Impact of distance on mode of active commuting in Chilean children and adolescents
(MDPI Multidisciplinary Digital Publishing Institute, 2017)
Active commuting could contribute to increasing physical activity. The objective of this study was to characterise patterns of active commuting to and from schools in children and adolescents in Chile. A total of 453 Chilean ...
Endoplasmic reticulum proteostasis impairment in aging
(Wiley-Blackwell Publishing Ltd, 2017)
Perturbed neuronal proteostasis is a salient feature shared by both aging and protein misfolding disorders. The proteostasis network controls the health of the proteome by integrating pathways involved in protein synthesis, ...
Fungal systematics and evolution: FUSE 3
(Verlag Ferdinand Berger und Sohne GmbH, 2017)
The present study introduces seven new species, one new combination, one new variety and several interesting taxonomical notes and/or geographical records. Most of the new taxa are Ascomycetes, but the study also includes ...
Efectos de la actividad física sobre la asociación entre obesidad y diabetes mellitus tipo 2: resultados de la encuesta nacional de salud 2009-2010
(Sociedad Médica de Santiago, 2017)
Background: Physical inactivity and obesity are major risk factors for type 2 diabetes (T2D). Aim: To investigate whether if the association between obesity and diabetes is modified by levels of physical activity in the ...
Mujeres chilenas en edad fértil: Su estado nutricional y la asociación con actividad física y hábitos alimentarios
(American Chemical Society, 2017)
Background: Women in Chile are mainly responsible in the formation of eating habits in the population, particularly at their homes. Aim: To explore the association of physical activity and alimentary habits with overweight ...
ERM proteins play distinct roles in cell invasion by extracellular amastigotes of Trypanosoma cruzi
(Frontiers Media S.A., 2017)
The protozoan parasite Trypanosoma cruzi is the causative agent of Chagas' disease. In mammalian hosts, T. cruzi alternates between trypomastigote and amastigote forms. Additionally, trypomastigotes can differentiate into ...
Collective memories and present-day intergroup relations: Introduction to the special thematic section
(PsychOpen, 2017)
This special thematic section aims to bring together current research on the connections between collective memories - or representations of history - and present-day intergroup relations. Drawing from a multitude of ...