• Nitrate in 2020: Thirty Years from Transport to Signaling Networks 

      Vidal, Elena A. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Alvarez, Jose M. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Araus, Viviana; Riveras, Eleodoro; Brooks, Matthew D.; Krouk, Gabriel; Ruffel, Sandrine; Lejay, Laurence; Crawford, Nigel M.; Coruzzi, Gloria M.; Gutierrez, Rodrigo A. (American Society of Plant Biologists, 2020-07)
      Nitrogen (N) is an essential macronutrient for plants and a major limiting factor for plant growth and crop production. Nitrate is the main source of N available to plants in agricultural soils and in many natural environments. ...
    • Non-lysosomal Activation in Macrophages of Atlantic Salmon (Salmo salar) After Infection With Piscirickettsia salmonis 

      Reyes-Cerpa, Sebastián [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Valdés, Jorge [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Ibaceta, Valentina [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Brianson, Bernardo [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Espinoza, Allison [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Ahumada, Diego E. [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Tapia, Sebastián [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Pérez-Stuardo, Diego [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Santiago, Chile]; Morales-Reyes, Jonathan; Espinoza, Allison; Soto-Herrera, Valentina; Sandino, Ana M.; Spencer, Eugenio; Vallejos-Vidal, Eva; Reyes-López, Felipe E. (FRONTIERS MEDIA SA, 2019)
      Piscirickettsia salmonis is a facultative intracellular pathogen and etiological agent of the systemic disease salmonid rickettsial septicemia. It has been suggested that P salmonis is able to survive in host macrophages, ...
    • Non-Specific Antibodies Induce Lysosomal Activation in Atlantic Salmon Macrophages Infected by Piscirickettsia salmonis 

      Pérez-Stuardo, Diego [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Espinoza, Allison [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Tapia, Sebastián [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Morales-Reyes, Jonathan; Barrientos, Claudio; Vallejos-Vidal, Eva; Sandino, Ana M.; Spencer, Eugenio; Toro-Ascuy, Daniela; Rivas-Pardo, J. Andrés [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Reyes-López, Felipe E.; Reyes-Cerpa, Sebastián [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile] (Frontiers Media S.A., 2020-11)
      Piscirickettsia salmonis, an aggressive intracellular pathogen, is the etiological agent of salmonid rickettsial septicemia (SRS). This is a chronic multisystemic disease that generates high mortalities and large losses ...
    • NOTCH3 Gene Mutation in a Chilean Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Family 

      Sánchez, Carolina [Univ Mayor, Ctr Genom & Bioinformat, Santiago, Chile]; Fonseca, Beatriz [Univ Mayor, Ctr Genom & Bioinformat, Santiago, Chile]; Rivera, Alejandra [Univ Mayor, Ctr Genom & Bioinformat, Santiago, Chile]; Latapiat, Verónica [Univ Mayor, Ctr Genom & Bioinformat, Santiago, Chile]; Gallardo, Andres; Roldan, Andres; Sandoval, Patricio; Manuel Matamala, Jose (ELSEVIER, 2020)
      Introduction: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary stroke disorder caused by mutations in the NOTCH3 gene. We report the first Chilean ...
    • Nutrient dose-responsive transcriptome changes driven by Michaelis Menten kinetics underlie plant growth rates 

      Swift, Joseph; Alvarez, Jose M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Araus, Viviana; Gutiérrez, Rodrigo A.; Coruzzi, Gloria M. (National Academy of Sciences, 2020-06-09)
      An increase in nutrient dose leads to proportional increases in crop biomass and agricultural yield. However, the molecular underpinnings of this nutrient dose-response are largely unknown. To investigate, we assayed changes ...
    • Outline of Fungi and fungus-like taxa 

      Wijayawardene, NN; Hyde, KD; Al-Ani, LKT; Tedersoo, L.; Haelewaters, D; Rajeshkumar, KC; Zhao, RL; Aptroot, A; Leontyev, DV; Saxena, RK; Tokarev, YS; Dai, DQ; Letcher, PM; Stephenson, SL; Ertz, D; Lumbsch, HT; Kukwa, M; Issi, IV; Phillips, AJL; Selbmann, L; Pfliegler, WP; Horvath, E; Bensch, K; Kirk, PM; Kolarikova, K; Raja, HA; Radek, R; Papp, V; Dima, B; Ma, J; Malosso, E; Takamatsu, S; Rambold, G; Gannibal, PB; Triebel, D; Gautam, AK; Avasthi, S; Suetrong, S; Timdal, E; Fryar, SC; Delgado, G; Reblova, M; Doilom, M; Dolatabadi, S; Pawlowska, JZ; Humber, RA; Kodsueb, R; Sanchez-Castro, I; Goto, BT; Silva, DKA; de Souza, FA; Oehl, FR; da Silva, GA; Silva, IR; Blaszkowski, J; Jobim, K; Maia, LC; Barbosa, FR; Fiuza, PO; Divakar, PK; Shenoy, BD; Castaneda-Ruiz, RF; Somrithipol, S; Lateef, AA; Karunarathna, SC; Tibpromma, S; Mortimer, PE; Wanasinghe, DN; Phookamsak, R; Xu, J; Wang, Y; Tian, F; Alvarado, P; Li, DW; Kusan, I; Matocec, N; Mesic, A; Tkalcec, Z; Maharachchikumbura, SSN; Papizadeh, M; Heredia, G; Wartchow, F; Bakhshi, M; Boehm, E; Youssef, N; Hustad, VP; Lawrey, JD; Santiago, ALCMA; Bezerra, JDP; Souza-Motta, CM; Firmino, AL; Tian, Q; Houbraken, J; Hongsanan, S; Tanaka, K; Dissanayake, AJ; Monteiro, JS; Grossart, HP; Suija, A; Weerakoon, G; Etayo, J; Tsurykau, A; Vazquez, V; Mungai, P ; Damm, U; Li, QR; Zhang, H; Boonmee, S; Lu, YZ; Becerra, AG; Kendrick, B; Brearley, FQ; Motiejunaite, J; Sharma, B; Khare, R; Gaikwad, S; Wijesundara, DSA; Tang, LZ; He, MQ; Flakus, A; Rodriguez-Flakus, P; Zhurbenko, MP; McKenzie, EHC; Stadler, M; Bhat, DJ; Liu, JK; Raza, M; Jeewon, R; Nassonova, ES; Prieto, M; Jayalal, RGU; Erdogdu, M; Yurkov, A; Schnittler, M; Shchepin, ON; Novozhilov, YK; Silva, AGS; Gentekaki, E; Liu, P; Cavender, JC; Kang, Y; Mohammad, S; Zhang, LF; Xu, RF; Li, YM; Dayarathne, MC; Ekanayaka, AH; Wen, TC; Deng, CY; Pereira, OL; Navathe, S; Hawksworth, DL; Fan, XL; Dissanayake, LS; Kuhnert, E; Thines, M; Madrid, H. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile] (Guizhou Key Laboratory of Agricultural Biotechnology, 2020)
      This article provides an outline of the classification of the kingdom Fungi (including fossil fungi. i.e. dispersed spores, mycelia, sporophores, mycorrhizas). We treat 19 phyla of fungi. These are Aphelidiomycota, Ascomycota, ...
    • Partitioning beta-diversity reveals that invasions and extinctions promote the biotic homogenization of Chilean freshwater fish fauna 

      Castro, Sergio A.; Rojas, Pablo; Vila, Irma; Habit, Evelyn; Pizarro-Konczak, Jaime; Jaksic, Fabian M.; Abades, Sebastián [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile] (Chile. Universidad Mayor, 2020)
      Aim Exotic species' introductions together with extinction of native species represent the main mechanisms driving biotic homogenization of freshwater fish assemblages around the world. While generally ichtyofaunistic ...
    • Phylogenomic analysis of the Porphyromonas gingivalis-Porphyromonas gulae duo: approaches to the origin of periodontitis 

      Morales-Olavarria, Mauricio [Univ Mayor, Fac Ciencias Ingn & Tecnol, Ctr Genom & Bioinformat, Chile]; Nuñez-Belmar, Josefa [Univ Mayor, Fac Ciencias Ingn & Tecnol, Ctr Genom & Bioinformat, Chile]; González, Damariz [Univ Mayor, Fac Ciencias Ingn & Tecnol, Ctr Genom & Bioinformat, Chile]; Vicencio, Emiliano; Rivas-Pardo, Jaime Andrés [Univ Mayor, Fac Ciencias Ingn & Tecnol, Ctr Genom & Bioinformat, Chile]; Cortez, Cristian; Cárdenas, Juan P. [Univ Mayor, Fac Ciencias Ingn & Tecnol, Ctr Genom & Bioinformat, Chile] (FRONTIERS MEDIA SA, 2023-07-19)
      Porphyromonas gingivalis is an oral human pathogen associated with the onset and progression of periodontitis, a chronic immune-inflammatory disease characterized by the destruction of the teeth-supporting tissue. P. ...
    • Pleione: A tool for statistical and multi-objective calibration of Rule-based models 

      Martin, Alberto J. M. [Univ Mayor, Fac Ciencias, Network Biol Lab, Ctr Genom & Bioinformat]; Santibáñez, Rodrigo [Univ Mayor, Fac Ciencias, Network Biol Lab, Ctr Genom & Bioinformat]; Garrido, Daniel (NATURE PUBLISHING GROUP, 2019)
      Mathematical models based on Ordinary Differential Equations (ODEs) are frequently used to describe and simulate biological systems. Nevertheless, such models are often difficult to understand. Unlike ODE models, Rule-Based ...
    • RIP-MD: a tool to study residue interaction networks in protein molecular dynamics 

      Contreras-Riquelme, Sebastián [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Network Biol Lab, Santiago, Chile]; Martín, Alberto J. M. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Network Biol Lab, Santiago, Chile]; Garate, José-Antonio; Pérez-Acle, Tomás (PEERJ INC, 2018)
      Protein structure is not static; residues undergo conformational rearrangements and, in doing so, create, stabilize or break non-covalent interactions. Molecular dynamics (MD) is a technique used to simulate these movements ...
    • Rule-Based Models and Applications in Biology 

      Bustos, Álvaro; Fuenzalida, Ignacio; Santibáñez, Rodrigo; Pérez-Acle, Tomás; Martin, Alberto J M [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (Humana Press, 2018-11-13)
      Complex systems are governed by dynamic processes whose underlying causal rules are difficult to unravel. However, chemical reactions, molecular interactions, and many other complex systems can be usually represented as ...
    • Signal peptide recognition in Trypanosoma cruzi GP82 adhesin relies on its localization at protein N-terminus 

      Cortez, Cristián [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Cordero, Esteban M. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Yoshida, Nobuko; da Silveira, JoséFranco (NATURE PUBLISHING GROUP, 2019)
      Trypanosoma cruzi, the causative agent of Chagas disease, has a dense coat of GPI-anchored virulence factors. T. cruzi GPI-anchored adhesin GP82 is encoded by a repertoire of transcripts containing several in-frame initiation ...
    • SinEx DB 2.0 update 2020: database for eukaryotic single-exon coding sequences 

      Jorquera, R; Clausen, PTLC; Petersen, B.; González, C. [Univ Mayor, Ctr Genom & Bioinformat, Chile]; Holmes, DS [Univ Mayor, Ctr Genom & Bioinformat, Chile] (Oxford University Press, 2021-01-28)
      Single-exon coding sequences (CDSs), also known as 'single-exon genes' (SEGs), are defined as nuclear, protein-coding genes that lack introns in their CDSs. They have been studied not only to determine their origin and ...
    • Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar) 

      Vallejos-Vidal, Eva; Reyes-Cerpa, Sebastián [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Rivas-Pardo, Jaime Andrés [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Maisey, Kevin; Yañez, José M.; Valenzuela, Héctor; Cea, Pablo A.; Castro-Fernández, Víctor; Tort, Lluis; Sandino, Ana M.; Imarai, Mónica; Reyes-López, Felipe E. (Frontiers Media S.A., 2020-02-27)
      Single-nucleotide polymorphisms (SNPs) are single genetic code variations considered one of the most common forms of nucleotide modifications. Such SNPs can be located in genes associated to immune response and, therefore, ...
    • SMZ/SNZ and gibberellin signaling are required for nitrate-elicited delay of flowering time in Arabidopsis thaliana 

      Vidal, Elena A. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Gras, Diana E.; Undurraga, Soledad F.; Riveras, Eleodoro; Moreno, Sebastián; Domínguez-Figueroa, José; Alabadi, David; Blazquez, Miguel A.; Medina, Joaquín; Gutiérrez, Rodrigo A. (OXFORD UNIV PRESS, 2018)
      The reproductive success of plants largely depends on the correct programming of developmental phase transitions, particularly the shift from vegetative to reproductive growth. The timing of this transition is finely ...
    • TGA class II transcription factors are essential to restrict oxidative stress in response to UV-B stress in Arabidopsis 

      Herrera-Vásquez, Ariel; Fonseca, Alejandro; Ugalde, José Manuel; Lamig, Liliana; Seguel, Aldo; Moyano, Tomas C.; Gutiérrez, Rodrigo A.; Salinas, Paula; Vidal, Elena A. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Holuigue, Loreto (OXFORD UNIV PRESS, 2021-02-27)
      Plants possess a robust metabolic network for sensing and controlling reactive oxygen species (ROS) levels upon stress conditions. Evidence shown here supports a role for TGA class II transcription factors as critical ...
    • The Microbial Composition in Circumneutral Thermal Springs from Chignahuapan, Puebla, Mexico Reveals the Presence of Particular Sulfur-Oxidizing Bacterial and Viral Communities 

      Castelan-Sánchez, Hugo Gildardo; Meza-Rodríguez, Pablo M.; Carrillo, Erika; Ríos-Vázquez, David I.; Linan-Torres, Arturo; Batista-Garcia, Ramón Alberto; Pérez-Rueda, Ernesto [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Rojas-Ruíz, Norma Elena; Dávila-Ramos, Sonia (MDPI AG, 2020-11)
      Terrestrial thermal springs are widely distributed globally, and these springs harbor a broad diversity of organisms of biotechnological interest. In Mexico, few studies exploring this kind of environment have been described. ...
    • The protein architecture in Bacteria and Archaea identifies a set of promiscuous and ancient domains 

      Hernández-Guerrero, Rafael; Galán-Vásquez, Edgardo; Pérez-Rueda, Ernesto [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (Public Library of Science, 2019-12-19)
      In this work, we describe a systematic comparative genomic analysis of promiscuous domains in genomes of Bacteria and Archaea. A quantitative measure of domain promiscuity, the weighted domain architecture score (WDAS), ...
    • Thinning alters the expression of the PpeSUT1 and PpeSUT4 sugar transporter genes and the accumulation of translocated sugars in the fruits of an early season peach variety 

      Núñez, Carlos [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Chile]; Dupre, German; Mujica, Karen; Melet, Lorena; Meisel, Lee; Miyasaka Almeida, Andrea [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Chile] (Chile. Universidad Mayor, 2019)
      Thinning is an agronomic practice that consists in the removal of a certain number of fruits, thereby altering the source-sink equilibrium in the tree and favoring carbon allocation to the remaining fruits. If thinning is ...
    • Tracing the phylogenetic history of the Crl regulon through the Bacteria and Archaea genomes 

      Pérez-Rueda, E. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Santos-Zavaleta, A.; Sánchez-Pérez, M.; Velazquez-Ramírez, D. A.; Collado-Vides, J. (BMC, 2019)
      Background: Crl, identified for curli production, is a small transcription factor that stimulates the association of the sigma(S) factor (RpoS) with the RNA polymerase core through direct and specific interactions, increasing ...


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