• Editorial: Physiological, biochemical and molecular approaches in response to abiotic stresses in plants 

      Camargo Mendes, Giselle; Mueller, Caroline; Miyasaka Almeida, Andrea [Univ Mayor, Ctr Genom & Bioinformat, Chile] (FRONTIERS MEDIA SA, 2023-04-21)
      Sin resumen.
    • Effect of CO2 Concentration on Uptake and Assimilation of Inorganic Carbon in the Extreme Acidophile Acidithiobacillus ferrooxidans 

      Holmes, David S.[Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Esparza, Mario; Jedlicki, Eugenia; González, Carolina; Dopson, Mark (FRONTIERS MEDIA SA, 2019)
      This study was motivated by surprising gaps in the current knowledge of microbial inorganic carbon (Ci) uptake and assimilation at acidic pH values (pH < 3). Particularly striking is the limited understanding of the ...
    • Effect of yeast (Xanthophyllomyces dendrorhous) and plant (Saint John's wort, lemon balm, and rosemary) extract based functional diets on antioxidant and immune status of Atlantic salmon (Salmo salar) subjected to crowding stress 

      Reyes-Cerpa, Sebastián [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Pérez-Stuardo, Diego [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Vallejos-Vidal, Eva; González-Brown, María José; Morales-Reyes, Jonathan; Vargas, Deborah; Imarai, Mónica; Cifuentes, Víctor; Spencer, Eugenio; Sandino, Ana María; Reyes-López, Felipe E. (ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2018)
      Salmon farming may face stress due to the intensive culture conditions with negative impacts on overall performance. In this aspect, functional feed improves not only the basic nutritional requirements but also the health ...
    • Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion 

      Kalempa Demeu, Lara Maria; Soares, Rodrigo Jahn; Miranda, Juliana Severo; Pacheco-Lugo, Lisandro A.; Oliveira, Kelin Goncalves; Cortez Plaza, Cristian Andres [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Billiald, Philippe; de Moura, Juliana Ferreira; Yoshida, Nobuko; Alvarenga, Larissa Magalhaes; DaRocha, Wanderson Duarte (Chile. Universidad Mayor, 2019-10-16)
      Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and the efficiency of the two drugs available is limited to the acute phase. Therefore, there is ...
    • Evaluation of the Abundance of DNA-Binding Transcription Factors in Prokaryotes 

      Pérez-Rueda, Ernesto [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat]; Sánchez, Israel; Hernández-Guerrero, Rafael; Méndez-Monroy, Paul Erick; Martínez-Nunez, Mario Alberto; Ibarra, JoséAntonio (MDPI, 2020)
      The ability of bacteria and archaea to modulate metabolic process, defensive response, and pathogenic capabilities depend on their repertoire of genes and capacity to regulate the expression of them. Transcription factors ...
    • Evolution of Predicted Acid Resistance Mechanisms in the Extremely Acidophilic Leptospirillum Genus 

      Vergara, Eva; Neira, Gonzalo; González, Carolina [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortez, Diego; Dopson, Mark; Holmes, David S. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (MDPI Multidisciplinary Digital Publishing Institute, 2020-04)
      Organisms that thrive in extremely acidic environments (<= pH 3.5) are of widespread importance in industrial applications, environmental issues, and evolutionary studies. Leptospirillum spp. constitute the only extremely ...
    • Filtering of Data-Driven Gene Regulatory Networks Using Drosophila melanogaster as a Case Study 

      Cuesta-Astroz, Yesid; Gischkow Rucatti, Guilherme [Univ Mayor, Fac Ciencias, Ctr Biol Integrat, Chile]; Murgas, Leandro [Univ Mayor, Lab Biol Redes, Ctr Genom & Bioinformat, Fac Ciencias, Chile]; SanMartin, Carol D.; Sanhueza, Mario [Univ Mayor, Fac Ciencias, Ctr Biol Integrat, Chile]; Martin, Alberto J. M. [Univ Mayor, Lab Biol Redes, Ctr Genom & Bioinformat, Fac Ciencias, Chile] (FRONTIERS MEDIA SA, 2021-07-28)
      Gene Regulatory Networks (GRNs) allow the study of regulation of gene expression of whole genomes. Among the most relevant advantages of using networks to depict this key process, there is the visual representation of large ...
    • Gadolinium Chloride Rescues Niemann-Pick Type C Liver Damage 

      Cortez, Cristián [Univ Mayor, Fac Sci, Ctr Genom & Bioinformat, Santiago 8580745, Chile]; Klein, Andrés D.; Esteban Oyarzún, Juan; Zanlungo, Silvana (MDPI, 2018)
      Niemann-Pick type C (NPC) disease is a rare neurovisceral cholesterol storage disorder that arises from loss of function mutations in the NPC1 or NPC2 genes. Soon after birth, some patients present with an aggressive ...
    • Gene Regulatory Networks of Penicillium echinulatum 2HH and Penicillium oxalicum 114-2 Inferred by a Computational Biology Approach 

      Lenz, Alexandre Rafael; Galán-Vásquez, Edgardo; Balbinot, Eduardo; de Abreu, Fernanda Pessi; Souza de Oliveira, Nikael; da Rosa, Leticia Osorio; de Avila e Silva, Scheila; Camassola, Marli; Dillon, Aldo Jose Pinheiro; Pérez-Rueda, Ernesto [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile] (Frontiers Media S.A., 2020-10)
      Penicillium echinulatum 2HH and Penicillium oxalicum 114-2 are well-known cellulase fungal producers. However, few studies addressing global mechanisms for gene regulation of these two important organisms are available so ...
    • Genome-based classification of Acidihalobacter prosperus F5 (=DSM 105917=JCM 32255) as Acidihalobacter yilgarnensis sp. nov 

      Khaleque, Himel Nahreen; González, Carolina [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Investigación de Genómica y Bioinformática]; Johnson, D Barrie; Kaksonen, Anna H.; Holmes, David S. [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Investigación de Genómica y Bioinformática]; Watkin, Elizabeth L. J. (MICROBIOLOGY SOCIETY, 2020-12)
      The genus Acidihalobacter has three validated species, Acidihalobacter ferrooxydans, Acidihalobacter prosperus and Acidihalobacter aeolinanus, all of which were isolated from Vulcano island, Italy. They are obligately ...
    • High quality RNA extraction from Maqui berry for its application in next-generation sequencing 

      Villacreses, Javier [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Blanc, Noelle [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Espinoza, Loreto [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Martínez, Camila [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Pastor, Gabriela [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Manque, Patricio [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Undurraga, Soledad F. [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Polanco, Víctor [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Sánchez, Carolina [Chile. Universidad Mayor. Centro de Genómica y Bioinformática] (CIENCIAS, 2016)
      Maqui berry (Aristotelia chilensis) is a native Chilean species that produces berries that are exceptionally rich in anthocyanins and natural antioxidants. These natural compounds provide an array of health benefits for ...
    • High-Quality Draft Genome Sequence of Bacillus amyloliquefaciens Strain 629, an Endophyte from Theobroma cacao 

      SantAnna, Brena M. M.; Marbach, Phellippe P. A.; De Souza, Jorge T.; Rojas-Herrera, Marcelo [Univ Mayor, Ctr Genom & Bioinformat, Chile]; Roque, Milton R. A.; Queiroz, Artur T. L. (Chile. Universidad Mayor, 2015)
      Bacillus amyloliquefaciens strain 629 is an endophyte isolated from Theobroma cacao L. Here, we report the draft genome sequence (3.9 Mb) of B. amyloliquefaciens strain 629 containing 16 contigs (3,903,367 bp), 3,912 coding ...
    • Identification and Unusual Properties of the Master Regulator FNR in the Extreme Acidophile Acidithiobacillus ferrooxidans 

      Holmes, David S. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Osorio, Hector; Mettert, Erin; Kiley, Patricia; Dopson, Mark; Jedlicki, Eugenia (FRONTIERS MEDIA SA, 2019)
      The ability to conserve energy in the presence or absence of oxygen provides a metabolic versatility that confers an advantage in natural ecosystems. The switch between alternative electron transport systems is controlled ...
    • Identification of functional signatures in the metabolism of the three cellular domains of life 

      Pérez-Rueda, Ernesto {Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Escobar-Turriza, Pedro; Hernández-Guerrero, Rafael; César Poot-Hernández, Augusto; Rodríguez-Vazquez, Katya; Ramírez-Prado, Jorge (PUBLIC LIBRARY SCIENCE, 2019)
      In order to identify common and specific enzymatic activities associated with the metabolism of the three cellular domains of life, the conservation and variations between the enzyme contents of Bacteria, Archaea, and ...
    • Identification of Modules With Similar Gene Regulation and Metabolic Functions Based on Co-expression Data 

      Pérez-Rueda, Ernesto [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Galán-Vásquez, Edgardo (FRONTIERS MEDIA SA, 2019)
      Biological systems respond to environmental perturbations and to a large diversity of compounds through gene interactions, and these genetic factors comprise complex networks. In particular, a wide variety of gene co-expression ...
    • Implications of Selective Autophagy Dysfunction for ALS Pathology 

      Vicencio, Emiliano [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Beltrán, Sebastián [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Labrador, Luis [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Manque, Patricio [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Nassif, Melissa [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Woehlbier, Ute [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (MDPI Multidisciplinary Digital Publishing Institute, 2020-02)
      Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. ...
    • Improved ontology for eukaryotic single-exon coding sequences in biological databases 

      Holmes, David S. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Jorquera, Roddy; González, Carolina; Clausen, Philip; Petersen, Bent (OXFORD UNIV PRESS, 2018)
      Efficient extraction of knowledge from biological data requires the development of structured vocabularies to unambiguously define biological terms. This paper proposes descriptions and definitions to disambiguate the term ...
    • In vitropropagation ofLeptocarpha rivularis, a native medicinal plant 

      Dorta, Fernando; Polanco, Víctor [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Chile]; Ramírez, Ingrid; Seeger, Michael; Madrid, Alejandro; Montenegro, Iván (Springer New York, 2020-12)
      Leptocarpha rivularis, commonly known as "palo negro", is a species of the Astereaceae family, endemic in the forests of Southern Chile. The extracts of this plant have medicinal properties attributable to its secondary ...
    • Influence of mobile genetic elements and insertion sequences in long- and short-term adaptive processes of Acidithiobacillus ferrooxidans strains 

      Moya-Beltrán, Ana; Gajdosik, Martin; Rojas-Villalobos, Camila; Beard, Simon; Mandl, Martin; Silva-García, Danitza [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Johnson, D. Barrie; Ramírez, Pablo; Quatrini, Raquel; Kucera, Jiri (NATURE PORTFOLIO, 2023-07-05)
      The recent revision of the Acidithiobacillia class using genomic taxonomy methods has shown that, in addition to the existence of previously unrecognized genera and species, some species of the class harbor levels of ...
    • Inhibitory effect of serotype a of Aggregatibacter actinomycetemcomitans on the increased destructive potential of serotype b 

      Cortez, Cristián [Univ Mayor, Ctr Genom & Bioinformat, Fac Sci, Santiago, Chile]; Rojas, Leticia; Melgar-Rodríguez, Samanta; Díaz-Zuniga, Jaime; Alvarez, Carla; Monasterio, Gustavo; Rojas, Carolina; Cafferata, Emilio A.; Hernández, Marcela; Carvajal, Paola; Vernal, Rolando (WILEY, 2020)
      Objective The serotype b of Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) induces higher cytokine production in dendritic cells (DCs) compared with the other serotypes. However, this increased immunostimulatory ...


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