• Uncovering the Mechanisms of Halotolerance in the Extremely Acidophilic Members of the Acidihalobacter Genus Through Comparative Genome Analysis 

      Holmes, David S. [Univ Mayor, Sci Life Fdn, Ctr Bioinformat & Genome Biol, Santiago, Chile]; González, Carolina [Univ Mayor, Sci Life Fdn, Ctr Bioinformat & Genome Biol, Santiago, Chile]; Khaleque, Himel N.; Shafique, Raihan; Kaksonen, Anna H.; Watkin, Elizabeth L. J. (FRONTIERS MEDIA SA, 2019)
      There are few naturally occurring environments where both acid and salinity stress exist together, consequently, there has been little evolutionary pressure for microorganisms to develop systems that enable them to deal ...
    • Understanding gold toxicity in aerobically-grown Escherichia coli 

      Muñoz-Villagrán, C.; Contreras, F.; Cornejo, F.; Figueroa, M.; Valenzuela-Bezanilla, D.; Luraschi, R.; Reinoso, C.; Rivas-Pardo, J. [Univ Mayor, Lab Biol Estruct, Ctr Genom & Bioinformat, Chile]; Vásquez, C.; Castro, M.; Arenas, F. (Chile. Universidad Mayor, 2020)
      Background There is an emerging field to put into practice new strategies for developing molecules with antimicrobial properties. In this line, several metals and metalloids are currently being used for these purposes, ...
    • Unlocking Survival Mechanisms for Metal and Oxidative Stress in the Extremely Acidophilic, Halotolerant Acidihalobacter Genus 

      Khaleque, Himel Nahreen; Fathollazadeh, Homayoun; González, Carolina [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Shafique, Raihan; Kaksonen, Anna H.; Holmes, David S. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Watkin, Elizabeth L.J. (MDPI Multidisciplinary Digital Publishing Institute, 2020-11-24)
      Microorganisms used for the biohydrometallurgical extraction of metals from minerals must be able to survive high levels of metal and oxidative stress found in bioleaching environments. The Acidihalobacter genus consists ...
    • Whole Genome Sequence, Variant Discovery and Annotation in Mapuche-Huilliche Native South Americans 

      Vizoso, Paula [Univ Mayor, Fac Ciencias, Ctr Propagac Conservac Vegetal CEPROVEG, Santiago, Chile]; Vidal, Elena A. [Univ Mayor, Fac Ciencias, Ctr Geneim Bioinformat, Santiago, Chile]; Moyano, Tomás C.; Bustos, Bernabe, I; Pérez-Palma, Eduardo; Moraga, Carol; Riveras, Eleodoro; Montecinos, Alejandro; Azocar, Lorena; Soto, Daniela C.; Vidal, Mabel; Di Genoval, Alex; Puschel, Klaus; Nurnberg, Peter; Buch, Stephan; Hampe, Jochen; Allende, Miguel L.; Cambiazo, Veronica; González, Mauricio; Hodar, Christian; Montecino, Martin; Muñoz-Espinoza, Claudia; Orellana, Ariel; Reyes-Jara, Angelica; Travisanyl, Dante; Moraga, Mauricio; Eyheramendy, Susana; Maass, Alejandro; De Ferrari, Giancarlo, V; Mique, Juan Francisco; Gutiérrez, Rodrigo A. (NATURE PUBLISHING GROUP, 2019)
      Whole human genome sequencing initiatives help us understand population history and the basis of genetic diseases. Current data mostly focuses on Old World populations, and the information of the genomic structure of Native ...
    • Whole-exome sequencing of oral epithelial dysplasia samples reveals an association with new genes 

      Adorno-Farias, Daniela; Nunes dos Santos, Jean; González-Arriagada, Wilfredo; Tarquinio, Sandra; Santibáñez Palominos, Rodrigo Alberto [Univ Mayor UMAYOR, Ctr Genom & Bioinformat, Sch Sci, Network Biol Lab, Santiago, Chile]; Martin Martin, Alberto Jesús; Fernández-Ramires, Ricardo (SOCIEDADE BRASILEIRA DE PESQUISA ODONTOLOGICA, 2023-03-23)
      The genetic basis of oral epithelial (OED) is unknown, and there is no reliable method for evaluating the risk of malignant transformation. Somatic mutations are responsible for the transformation of dysplastic mucosa to ...


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