Now showing items 16-35 of 88

    • Ca2+ transfer to mitochondria: a spark of life in unexpected conditions 

      Silva-Pavez, E. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Ahumada-Castro, U. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Lovy, Alenka [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Cárdenas, Julio César [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile] (Chile. Universidad Mayor, 2020)
      The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca2+) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells ...
    • Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival 

      Cárdenas, César [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Lovy, Alenka [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Silva-Pavez, Eduardo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Urra, Felix; Mizzoni, Craig; Ahumada-Castro, Ulises; Bustos, Galdo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Jana, Fabián; Cruz, Pablo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Farías, Paula [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Mendoza, Elizabeth [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Huerta, Hernán [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Murgas, Paola [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Hunter, Martin; Róos, Melany [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cerda, Oscar; Georgakoudi, Irene; Zakarian, Armen; Molgo, Jordi; Foskett, J. Kevin (American Association for the Advancement of Science, 2020-07)
      Spontaneous Ca2+ signaling from the InsP(3)R intracellular Ca2+ release channel to mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP production. In cells with defective OXPHOS, reductive ...
    • CD73 Ectonucleotidase Restrains CD8+T Cell Metabolic Fitness and Anti-tumoral Activity 1 of 1 CD73 Ectonucleotidase Restrains CD8+T Cell Metabolic Fitness and Anti-tumoral Activity 

      Briceño, Pedro; Rivas-Yañez, Elizabeth; Rosemblatt, Mariana V.; Parra-Tello, Brian; Vargas, Leonardo; Lladser, Alvaro; Salazar-Onfray, Flavio; Elorza, Alvaro A.; Rosemblatt, Mario; Bono, Maria Rosa; Sauma, Daniela; Farias, Paula; Cardenas, Cesar [Univ Mayor, Ctr Integrat Biol, Chile] (FRONTIERS MEDIA SA, 2021-02-18)
      CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ...
    • Clinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome 

      Sanhueza, Sergio; Vidal, Mabel A.; Hernández, Mauricio A.; Henríquez-Beltrán, Mario E.; Cabrera, Camilo; Quiroga, Romina; Antilef, Bárbara E.; Aguilar, Kevin P.; Castillo, Daniela A.; Llerena, Faryd J.; Fraga Figueroa, Marco; Nazal, Mauricio; Castro, Eritson; Lagos, Paola; Moreno, Alexa; Lastra, Jaime J.; Gajardo, Jorge; Garcés, Pamela; Riffo, Benilde; Buchert, Jorge; Sanhueza, Rocío; Ormazábal, Valeska; Saldivia, Pablo; Vargas, Cristian; Nourdin, Guillermo; Koch, Elard; Zúñiga, Felipe A.; Lamperti, Liliana; Bustos, Paula; Guzmán-Gutiérrez, Enrique; Tapia, Claudio A.; Ferrada, Luciano; Cerda, Gustavo; Woehlbier, Ute [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Riquelme, Erick; Yuseff, María-Isabel; Muñoz Ramírez, Braulio A.; Lombardi, Giovanna; Gonzalo-Calvo, David de; Salomón, Carlos; Verdugo, Ricardo A.; Quiñones, Luis A.; Colombo, Alicia; Barría, María I.; Labarca, Gonzalo; Nova-Lamperti, Estefania (Frontiers Media S.A., 2023-10)
      Introduction: Long-term pulmonary dysfunction (L-TPD) is one of the most critical manifestations of long-COVID. This lung affection has been associated with disease severity during the acute phase and the presence of ...
    • Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile 

      Lemaitre, Dominique; Llavero Hurtado, Maica; De Gregorio, Cristian; Onate, Maritza; Martínez, Gabriela; Catenaccio, Alejandra [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Wishart, Thomas M.; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Humana Press, 2020-10)
      Peripheral nerve injuries result in motor and sensory dysfunction which can be recovered by compensatory or regenerative processes. In situations where axonal regeneration of injured neurons is hampered, compensation by ...
    • Compartmentalized necroptosis activation in excitotoxicity-induced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology 

      Arrazola, Macarena S. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2019-08)
      Sin resumen.
    • Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca(2+)Transfer to Mitochondria 

      Lovy, Alenka [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Ahumada-Castro, Ulises [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Bustos, Galdo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Farias, Paula [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Gonzalez-Billault, Christian [Univ Mayor, Fac Sci, Gerosci Ctr Brain Hlth & Metab, Chile]; Molgo, Jordi; Cardenas, Cesar [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Frontiers Media S.A., 2020-05)
      Mitochondria are highly dynamic organelles constantly undergoing fusion and fission. Ca(2+)regulates many aspects of mitochondrial physiology by modulating the activity of several mitochondrial proteins. We previously ...
    • Conversatorio: Hacia el envejecimiento saludable en Chile 

      Manque, Patricio [Chile. Universidad Mayor. Vicerrectoría de Investigación]; González, Ana Rita; Court, Felipe [Chile. Universidad Mayor. Centro de Biología Integrativa]; Thumala, Daniela [Chile. Universidad Mayor. Centro de Gerociencia, Salud Mental y Metabolismo]; Sola, Juan Carlos [Abbott Nutrition]; Vergara, Octavio [Chile. Senama]; Guzmán, Eghon [Asocimed]; Paris, Enrique [Chile. Ministerio de Salud] (Chile. Universidad Mayor, 2021-01-21)
      El conversatorio en línea "Hacia el envejecimiento saludable en Chile" organizado por la Facultad de Ciencias de la Universidad Mayor y Abbott, compañía multinacional de alta tecnología en salud. En la convocatoria, ...
    • Correction: The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease (vol 32, pg 274, 2019) 

      Oñate, Maritza [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Catenaccio, Alejandra [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Salvadores, Natalia [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Saquel, Cristian [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Martínez, Alexis; Moreno-González, Inés; Gamez, Nazaret; Soto, Paulina; Soto, Claudio; Hetz, Claudio; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (Chile. Universidad Mayor, 2020-07)
      Correction to: Cell Death & Differentiation https://doi.org/10.1038/s41418-019-0408-4. Since online publication of this article, the authors noticed that reference details provided for references 65 and 66 were incorrect. ...
    • Decoding Gene Networks Modules That Explain the Recovery of Hymenoglossum cruentum Cav. After Extreme Desiccation 

      Ostria-Gallardo, Enrique; Larama, Giovanni; Berrios, Graciela; Fallard, Ana; Gutiérrez-Moraga, Ana; Ensminger, Ingo; Manque, Patricio [Univ Mayor, Ctr Integrat Biol, Chile]; Bascuñán-Godoy, Luisa; Bravo, León A. (Frontiers Media S.A., 2020-05)
      Hymenoglossum cruentum (Hymenophyllaceae) is a poikilohydric, homoiochlorophyllous desiccation-tolerant (DT) epiphyte fern. It can undergo fast and frequent dehydration-rehydration cycles. This fern is highly abundant at ...
    • Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model 

      Bargsted L., Medinas D.B., Martínez Traub F., Rozas P., Muñoz N., Jerez C., Court F.A., Hetz C., Matus S.; Nassif, Melissa [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Catenaccio, Alejandra [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile] (Nature Publishing Group, 2017)
      Tar DNA binding protein 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tissue of most cases of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ...
    • Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein 

      Nassif, Melissa [Univ Mayor, Fac Sci, Ctr Integrat Biol, Lab Neuroprotect & Autophagy, Santiago, Chile]; Gómez, Wileidy [Univ Mayor, Fac Sci, Ctr Integrat Biol, Lab Neuroprotect & Autophagy, Santiago, Chile]; Morales, Rodrigo; Maracaja-Coutinho, Vinicius; Parra, Valentina (IMPACT JOURNALS LLC, 2020)
      Alzheimer's disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the leading genetic risk factor for Early-Onset AD, prematurely presenting the classic pathological features of the brain with AD. ...
    • Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis 

      Woehlbier, Ute [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Medinas, Danilo B.; Rozas, Pablo; Martínez Traub, Francisca; Brown, Robert H.; Bosco, Daryl A.; Hetz, Claudio (NATL ACAD SCIENCES, 2018)
      Abnormal modifications to mutant superoxide dismutase 1 (SOD1) are linked to familial amyotrophic lateral sclerosis (fALS). Misfolding of wild-type SOD1 (SOD1(WT)) is also observed in postmortem tissue of a subset of ...
    • Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain 

      Gorostieta-Salas, Elisa; Moreno-Blas, Daniel; Gerónimo-Olvera, Cristian [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cisneros, Bulmaro; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Castro-Obregón, Susana (HINDAWI LTD, 2021-08-16)
      Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such ...
    • Filtering of Data-Driven Gene Regulatory Networks Using Drosophila melanogaster as a Case Study 

      Cuesta-Astroz, Yesid; Gischkow Rucatti, Guilherme [Univ Mayor, Fac Ciencias, Ctr Biol Integrat, Chile]; Murgas, Leandro [Univ Mayor, Lab Biol Redes, Ctr Genom & Bioinformat, Fac Ciencias, Chile]; SanMartin, Carol D.; Sanhueza, Mario [Univ Mayor, Fac Ciencias, Ctr Biol Integrat, Chile]; Martin, Alberto J. M. [Univ Mayor, Lab Biol Redes, Ctr Genom & Bioinformat, Fac Ciencias, Chile] (FRONTIERS MEDIA SA, 2021-07-28)
      Gene Regulatory Networks (GRNs) allow the study of regulation of gene expression of whole genomes. Among the most relevant advantages of using networks to depict this key process, there is the visual representation of large ...
    • Fishing forward and reverse: Advances in zebrafish phenomics 

      Letelier, Joaquín [Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Santiago, Chile]; Fuentes, Ricardo; Tajer, Benjamin; Mullins, Mary C. (ELSEVIER, 2018)
      Understanding how the genome instructs the phenotypic characteristics of an organism is one of the major scientific endeavors of our time. Advances in genetics have progressively deciphered the inheritance, identity and ...
    • GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly 

      Slachevsky, Andrea; Zitko, Pedro; Martínez-Pernia, David; Forno, Gonzalo; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Lillo, Patricia; Villagra, Roque; Durán-Aniotz, Claudia; Parrao, Teresa; Assar, Rodrigo; Orellana, Paulina; Toledo, Carolina; Rivera, Rodrigo; Ibañez, Agustín; Parra, Mario A.; Gonzalez-Billault, Christian; Amieva, Helena; Thumala, Daniela (BioMed Central Ltd., 2020-12)
      BackgroundWith the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and ...
    • Herpes simplex virus type 1 neuronal infection perturbs golgi apparatus integrity through activation of src tyrosine kinase and Dyn-2 GTPase 

      Martin C., Leyton L., Hott M., Arancibia Y., Spichiger C., McNiven M.A., Concha M.I., Burgos P.V., Otth C.; Court, Felipe A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile] (Frontiers Media S.A., 2017)
      Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen that establishes a latent persistent neuronal infection in humans. The pathogenic effects of repeated viral reactivation in infected neurons are still unknown. ...
    • Homozygous mutation in CEP19, a gene mutated in morbid obesity, in Bardet-Biedl syndrome with predominant postaxial polydactyly 

      Woehlbier, Ute [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Bolukbasi, Esra Yildiz; Mumtaz, Sara; Afzal, Muhammad; Malik, Sajid; Tolun, Aslihan (BMJ PUBLISHING GROUP, 2018)
      Background Bardet-Biedl syndrome (BBS) is a ciliopathy with extensive phenotypic variability and genetic heterogeneity. We aimed to discover the gene mutated in a consanguineous kindred with multiple cases of a BBS phenotype. ...
    • Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation 

      Montecinos-Oliva, Carla; Arrázola, Macarena S. [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Jara, Claudia; Tapia-Rojas, Cheril; Inestrosa, Nibaldo C. (MDPI Multidisciplinary Digital Publishing Institute, 2020-02)
      Alzheimer's Disease (AD) is the primary cause of dementia among the elderly population. Elevated plasma levels of homocysteine (HCy), an amino acid derived from methionine metabolism, are considered a risk factor and ...


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