Now showing items 32-51 of 88

    • GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly 

      Slachevsky, Andrea; Zitko, Pedro; Martínez-Pernia, David; Forno, Gonzalo; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Lillo, Patricia; Villagra, Roque; Durán-Aniotz, Claudia; Parrao, Teresa; Assar, Rodrigo; Orellana, Paulina; Toledo, Carolina; Rivera, Rodrigo; Ibañez, Agustín; Parra, Mario A.; Gonzalez-Billault, Christian; Amieva, Helena; Thumala, Daniela (BioMed Central Ltd., 2020-12)
      BackgroundWith the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and ...
    • Herpes simplex virus type 1 neuronal infection perturbs golgi apparatus integrity through activation of src tyrosine kinase and Dyn-2 GTPase 

      Martin C., Leyton L., Hott M., Arancibia Y., Spichiger C., McNiven M.A., Concha M.I., Burgos P.V., Otth C.; Court, Felipe A. [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile] (Frontiers Media S.A., 2017)
      Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen that establishes a latent persistent neuronal infection in humans. The pathogenic effects of repeated viral reactivation in infected neurons are still unknown. ...
    • Homozygous mutation in CEP19, a gene mutated in morbid obesity, in Bardet-Biedl syndrome with predominant postaxial polydactyly 

      Woehlbier, Ute [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Bolukbasi, Esra Yildiz; Mumtaz, Sara; Afzal, Muhammad; Malik, Sajid; Tolun, Aslihan (BMJ PUBLISHING GROUP, 2018)
      Background Bardet-Biedl syndrome (BBS) is a ciliopathy with extensive phenotypic variability and genetic heterogeneity. We aimed to discover the gene mutated in a consanguineous kindred with multiple cases of a BBS phenotype. ...
    • Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation 

      Montecinos-Oliva, Carla; Arrázola, Macarena S. [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Jara, Claudia; Tapia-Rojas, Cheril; Inestrosa, Nibaldo C. (MDPI Multidisciplinary Digital Publishing Institute, 2020-02)
      Alzheimer's Disease (AD) is the primary cause of dementia among the elderly population. Elevated plasma levels of homocysteine (HCy), an amino acid derived from methionine metabolism, are considered a risk factor and ...
    • Idiopathic inflammatory myopathy human derived cells retain their ability to increase mitochondrial function 

      Basualto-Alarcon, Carla; Urra, Felix A.; Bozan, María Francisca; Jana, Fabián; Trangulao, Alejandra; Bevilacqua, Jorge A.; Cárdenas, J. César [Univ Mayor, Fac Sci, Lab Cellular Metab & Bioenerget, Ctr Integrat Biol, Chile] (Public Library of Science, 2020-11)
      Idiopathic Inflammatory Myopathies (IIMs) have been studied within the framework of autoimmune diseases where skeletal muscle appears to have a passive role in the illness. However, persiting weakness even after resolving ...
    • IL-22-expressing CD4(+)AhR(+) T lymphocytes are associated with RANKL-mediated alveolar bone resorption during experimental periodontitis 

      Monasterio, Gustavo; Budini, Victoria; Fernández, Baltasar; Castillo, Francisca; Rojas, Carolina; Alvarez, Carla; Cafferata, Emilio A.; Vicencio, Emiliano [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortés, Bastian I. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortez, Cristian Andres [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Vernal, Rolando (Blackwell Munksgaard, 2019-10)
      Background and Objective Over the past few years, the importance of interleukin-22 (IL-22) and T-helper (Th)22 lymphocytes in the pathogenesis of periodontitis has become apparent; however, there are still aspects that are ...
    • Implications of Selective Autophagy Dysfunction for ALS Pathology 

      Vicencio, Emiliano [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Beltrán, Sebastián [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Labrador, Luis [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Manque, Patricio [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Nassif, Melissa [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Woehlbier, Ute [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (MDPI Multidisciplinary Digital Publishing Institute, 2020-02)
      Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. ...
    • In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes 

      Ahumada-Castro, Ulises [Univ Mayor, Gerosci Ctr Brain Hlth & Metab, Ctr Integrat Biol, Fac Sci, Chile]; Bustos, Galdo [Univ Mayor, Gerosci Ctr Brain Hlth & Metab, Ctr Integrat Biol, Fac Sci, Chile]; Silva-Pavez, Eduardo [Univ Mayor, Gerosci Ctr Brain Hlth & Metab, Ctr Integrat Biol, Fac Sci, Chile]; Puebla-Huerta, Andrea [Univ Mayor, Gerosci Ctr Brain Hlth & Metab, Ctr Integrat Biol, Fac Sci, Chile]; Lovy, Alenka [Univ Mayor, Gerosci Ctr Brain Hlth & Metab, Ctr Integrat Biol, Fac Sci, Chile]; Cardenas, Cesar [Univ Mayor, Gerosci Ctr Brain Hlth & Metab, Ctr Integrat Biol, Fac Sci, Chile] (FRONTIERS MEDIA SA, 2021-03-22)
      In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol ...
    • In Vitro Analysis of the Role of Schwann Cells on Axonal Degeneration and Regeneration Using Sensory Neurons from Dorsal Root Ganglia 

      López-Leal, Rodrigo [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Díaz, Paula [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (Humana Press, 2018)
      Sensory neurons from dorsal root ganglion efficiently regenerate after peripheral nerve injuries. These neurons are widely used as a model system to study degenerative mechanisms of the soma and axons, as well as regenerative ...
    • In Vivo Antitumor Effect against Murine Cells of CT26 Colon Cancer and EL4 Lymphoma by Autologous Whole Tumor Dead Cells 

      Barrera-Avalos, Carlos; Diaz, Ximena; Madrid, Bastian; Michelson, Sofia A.; Robles-Planells, Claudia; Sanchez-Guerrero, Giselle; Ahumada, Viviana; Mella-Torres, Andrea; Rojo, Leonel E.; Imarai, Monica; Milla, Luis A.; Leiva-Salcedo, Elias; Fernandez, Ricardo; Escobar, Alejandro; Acuña-Castillo, Claudio; Murgas, Paola [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (HINDAWI LTD, 2021-03-14)
      Active immunotherapy against cancer is based on immune system stimulation, triggering efficient and long-lasting antigen-specific immune responses. Immunization strategies using whole dead cells from tumor tissue, containing ...
    • Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells 

      Cruz, Pablo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Ahumada-Castro, Ulises [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Bustos, Galdo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Molgo, Jordi; Sauma, Daniela; Lovy, Alenka [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cárdenas, Cesar [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (MDPI, 2021-01)
      T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial ...
    • Injury to the nervous system: A look into the ER 

      Oñate, Maritza [Chile. Universidad Mayor]; Hetz, Claudio [Universidad de Chile]; Court, Felipe A [Chile. Universidad Mayor] (CIENCIAS, 2016)
      Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex ...
    • Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates 

      García-Huerta, Paula; Troncoso-Escudero, Paulina Oñate, Maritza [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Wu, Di; Thiruvalluvan, Arun; Cisternas-Olmedo, Marisol [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Henríquez, Daniel R.; Plate, Lars; Chana-Cuevas, Pedro; Saquel, Cristian [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Thielen, Peter; Longo, Kenneth A.; Geddes, Brad J.Lederkremer, Gerardo Z.; Sharma, Neeraj; Shenkman, Marina; Naphade, Swati; Sardi, S. Pablo; Spichiger, Carlos; Richter, Hans G.; Court, Felipe A.; Tshilenge, Kizito Tshitoko; Ellerby, Lisa M.; Wiseman, R. Luke; Gonzalez-Billault, Christian; Bergink, Steven; Vidal, Rene L.; Hetz, Claudio (SPRINGER, 2020-11)
      Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription ...
    • Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer 

      Zhang, Yu; Chandra, Vidhi; Riquelme Sanchez, Erick [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Dutta, Prasanta; Quesada, Pompeyo R.; Rakoski, Amanda; Zoltan, Michelle; Arora, Nivedita; Baydogan, Seyda; Horne, William; Burks, Jared; Xu, Hanwen; Hussain, Perwez; Wang, Huamin; Gupta, Sonal; Maitra, Anirban; Bailey, Jennifer M.; Moghaddam, Seyed J.; Banerjee, Sulagna; Sahin, Ismet; Bhattacharya, Pratip; McAllister, Florencia (Rockefeller University Press, 2020-12)
      Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with an immunosuppressive microenvironment that is resistant to most therapies. IL17 is involved in pancreatic tumorigenesis, but its role in invasive ...
    • IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A 

      Vidal, Rene L. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Rivera, Claudia A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Court, Felipe A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Urra, Hery; Henriquez, Daniel R.; Canovas, José; Villarroel-Campos, David; Carreras-Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Alvarez-Rojas, Sebastián; Figueroa, Ricardo; Rodríguez, Diego A.; Couve, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic, Alvaro; González-Billault, Christian; Hetz, Claudio (NATURE PUBLISHING GROUP, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
    • IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivation 

      Gómora-García, Juan Carlos; Gerónimo-Olvera, Cristian [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Pérez-Martínez, Xochitl; Massieu, Lourdes (SPRINGER NATURE, 2021-06-03)
      Altered protein homeostasis is associated with neurodegenerative diseases and acute brain injury induced under energy depletion conditions such as ischemia. The accumulation of damaged or unfolded proteins triggers the ...
    • Keeping zombies alive: The ER-mitochondria Ca2+ transfer in cellular senescence 

      Ahumada-Castro, Ulises [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Puebla-Huerta, Andrea [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cuevas-Espinoza, Victor [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Lovy, Alenka [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cesar Cardenas, J. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (ELSEVIER, 2021-08-31)
      Cellular senescence generates a permanent cell cycle arrest, characterized by apoptosis resistance and a pro-inflammatory senescence-associated secretory phenotype (SASP). Physiologically, senescent cells promote tissue ...
    • Levels of low-molecular-weight hyaluronan in periodontitis-treated patients and its immunostimulatory effects on CD4+ T lymphocytes 

      Castillo, Francisca; Monasterio, Gustavo; Ibarra, Juan; Guevara, José; Cafferata, Emilio A.; Carvajal, Paola; Vernal, Rolando; Vicencio, Emiliano [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cortez, Cristian [Univ Mayor, Fac Sci, Ctr Genom & Bioinformat, Chile] (SPRINGER HEIDELBERG, 2021-02-26)
      Objectives During periodontitis, chronic inflammation triggers soft tissue breakdown, and hyaluronan is degraded into fragments of low molecular weight (LMW-HA). This investigation aimed to elucidate whether LMW-HA fragments ...
    • Linked homozygous BMPR1B and PDHA2 variants in a consanguineous family with complex digit malformation and male infertility 

      Woehlbier, Ute [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Yildirim, Yeserin; Ouriachi, Toufik; Ouahioune, Wahiba; Balkan, Mahmut; Malik, Sajid; Tolun, Aslihan (NATURE PUBLISHING GROUP, 2018)
      In affected members of a consanguineous family, a syndrome, which is concurrence of set of medical signs, is often observed and commonly assumed to have arisen from pleiotropy, i.e., the phenomenon of a single gene variant ...
    • Metformin protects from oxaliplatin induced peripheral neuropathy in rats 

      Martinez, N W [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Sánchez, A.; Diaz, P.; Broekhuizen, R.; Godoy, J.; Mondaca, S.; Catenaccio, A. [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Macanas, P.; Nervi, B.; Calvo, M.; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Elsevier BV, 2020-08)
      Oxaliplatin is a commonly used drug to treat cancer, extending the rate of disease-free survival by 20% in colorectal cancer. However, oxaliplatin induces a disabling form of neuropathy resulting in more than 60% of patients ...


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