Now showing items 60-79 of 88

    • On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson's and Huntington's Disease 

      Troncoso-Escudero, Paulina [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Sepúlveda, Denisse [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Pérez-Arancibia, Rodrigo [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Parra, Alejandra V. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Arcos, Javiera [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Grunenwald, Felipe [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Vidal, Rene L. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile] (Frontiers Media S.A., 2020-09)
      Movement disorders are neurological conditions in which patients manifest a diverse range of movement impairments. Distinct structures within the basal ganglia of the brain, an area involved in movement regulation, are ...
    • Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium? 

      Alvarez, Jaime [Chile. Universidad Mayor. Facultad de Ciencias]; Court, Felipe A. [Chile. Universidad Mayor. Facultad de Ciencias] (CIENCIAS, 2016)
      The structural homeostasis is challenging for neurons, whose axons extend up to meters in large animals, and the axoplasmic mass reaches over a thousand times that of the cell body. Thus, the protein demand may overcome ...
    • Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease 

      Troncoso-Escudero, Paulina [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Parra, Alejandra [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Nassif, Melissa [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Vidal, Rene L. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile] (FRONTIERS MEDIA SA, 2018)
      Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central ...
    • P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis 

      Wisniewski, Laura; French, Vanessa; Lockwood, Nicola; Valdivia, Leonardo E. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Frankel, Paul (Nature Publishing Group, 2020-09)
      P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF ...
    • Pangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts 

      Costa, Daniela; Levesque, Simón; Kumar, Nitin; Fresia, Pablo; Ferres, Ignacio; Lawley, Trevor D.; Iraola, Gregorio [Univ Mayor, Ctr Integrat Biol, Chile] (NATURE PORTFOLIO, 2021-02-09)
      Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which ...
    • Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells 

      Pérez-Moreno, Pablo; Quezada-Meza, Camila; Chavez-Almarza, Cristopher; Niechi, Ignacio; Silva-Pavez, Eduardo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Trigo-Hidalgo, César; Aguayo, Francisco; Jara, Lilian; Cáceres-Verschae, Albano; Varas-Godoy, Manuel; Díaz, Víctor M.; García de Herreros, Antonio; Burzio, Veronica A.; Tapia, Julio C. (Frontiers Media S.A., 2020-07)
      Endothelin-converting enzyme-1 (ECE1) activates the endothelin-1 peptide, which upregulates pathways that are related to diverse hallmarks of cancer. ECE1 is expressed as four isoforms differing in their N-terminal domains. ...
    • Poly(ethylene imine)-chitosan carbon dots: study of its physical-chemical properties and biological in vitro performance 

      Santos, Nicolás [Escuela de Biotecnología, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chile]; Valenzuela, Santiago; Segura, Camilo; Osorio-Román, Igor; Arrázola, Macarena S. [Centro de Biología Integrativa, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chile]; Panadero-Medianero, Concepción [Centro de Biología Integrativa, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chile]; Santana, Paula A.; Ahumada, Manuel [Escuela de Biotecnología, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Chile] (Springer New York, 2023-10-17)
      Carbon dots (CDs) have been quickly extended for nanomedicine uses because of their multiple applications, such as bioimaging, sensors, and drug delivery. However, the interest in increasing their photoluminescence properties ...
    • Protein Kinase CK2 in Cancer Energetics 

      Silva-Pavez, Eduardo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Tapia, Julio C. (Frontiers Media S.A., 2020-06)
      Protein kinase CK2 (formerly known as casein kinase 2) is abnormally elevated in many cancers. This may increase tumor aggressiveness through CK2-dependent phosphorylation of key proteins in several signaling pathways. In ...
    • Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs 

      Gregorio, Cristian de [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Díaz, Paula [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; López-Leal, Rodrigo [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Manque, Patricio [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (Humana Press, 2018)
      Exosomes are small (30-150 nm) vesicles of endosomal origin secreted by most cell types. Exosomes contain proteins, lipids, and RNA species including microRNA, mRNA, rRNA, and long noncoding RNAs. The mechanisms associated ...
    • Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo 

      Krasnow, Anna M.; Ford, Marc C.; Valdivia, Leonardo E. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Wilson, Stephen W.; Attwell, David (NATURE PUBLISHING GROUP, 2018-01)
      How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high ...
    • La Ruta del Pensamiento: una mirada actual al cáncer en Chile 

      Riquelme, Erick [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Biología Integrativa] (Chile. Universidad Mayor, 2021-08-20)
      El Doctor en Ciencias Biológicas e investigador del Centro de Biología Integrativa de la Universidad Mayor, Erick Riquelme, aborda el proceso de los tumores, los principales tratamientos, los últimos hallazgos para futuros ...
    • La Ruta del Pensamiento: ¿Qué sabemos de las enfermedades que afectan al cerebro? 

      Vidal, René [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Biología Integrativa] (Chile. Universidad Mayor, 2021-07-28)
      René Vidal, Doctor en Ciencias y académico del Centro de Biología Integrativa U. Mayor, realizó el webinar “¿Qué sabemos de las enfermedades que afectan al cerebro?”, donde profundizó en su funcionamiento y qué ocurre ...
    • Salmonella Type III Secretion Effector SrfJ: A Glucosylceramidase Affecting the Lipidome and the Transcriptome of Mammalian Host Cells 

      Aguilera-Herce, Julia; Panadero-Medianero, Concepción [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Sánchez-Romero, María Antonia; Balbontín, Roberto; Bernal-Bayard, Joaquín; Ramos-Morales, Francisco (MDPI, 2023-05-07)
      Type III secretion systems are found in many Gram-negative pathogens and symbionts of animals and plants. Salmonella enterica has two type III secretion systems associated with virulence, one involved in the invasion of ...
    • Schwann cell and axon: An interlaced unit—From action potential to phenotype expression 

      Court, Felipe A. [Chile. Universidad Mayor. Center for Integrative Biology]; Alvarez, Jaime [Pontificia Universidad Católica de Chile. Millenium Nucleus for Regenerative Biology] (Facultad de Ciencias, 2016)
      Here we propose a model of a peripheral axon with a great deal of autonomy from its cell body-the autonomous axon-but with a substantial dependence on its ensheathing Schwann cell (SC), the axon-SC unit. We review evidence ...
    • Schwann cell reprogramming into repair cells increases miRNA-21 expression in exosomes promoting axonal growth 

      López-Leal, Rodrigo [Univ Mayor, Fac & Sci, Ctr Integrat Biol, Chile]; Díaz-Viraque, Florencia; Catalán, Romina J. [Univ Mayor, Fac & Sci, Ctr Integrat Biol, Chile]; Saquel, Cristian [Univ Mayor, Fac & Sci, Ctr Integrat Biol, Chile]; Enright, Anton; Iraola, Gregorio [Univ Mayor, Fac & Sci, Ctr Integrat Biol, Chile]; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Company of Biologists Ltd, 2020-06)
      Functional recovery after peripheral nerve damage is dependent on the reprogramming of differentiated Schwann cells (dSCs) into repair Schwann cells (rSCs), which promotes axonal regeneration and tissue homeostasis. ...
    • Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury 

      Geronimo-Olvera, Cristian [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Girardi, Karina [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Necuñir-Ibarra, David [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Kumar Patel, Sandip; Bons, Joanna; Wright, Megan C.; Geschwind, Daniel; Hoke, Ahmet; Gómez-Sánchez, José A.; Schilling, Birgit; Rebolledo, Daniela L. [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Campisi, Judith; Court, Felipe A. [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile] (Wiley-Blackwell, 2023-12-07)
      Following peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell (SC) reprogramming into a reparative phenotype, a process dependent upon c-Jun transcription factor activation. ...
    • Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation 

      Rojas-Rivera, Diego [Univ Mayor, Fac Sci, Ctr Integrat Biol]; Dondelinger, Yves; Delanghe, Tom; Priem, Dario; Wynosky-Dolfi, Meghan A.; Sorobetea, Daniel; Giansanti, Piero; Roelandt, Ria; Gropengiesser, Julia; Ruckdeschel, Klaus; Savvides, Savvas N.; Heck, Albert J. R.; Vandenabeele, Peter; Brodsky, Igor E.; Bertrand, Mathieu J. M. (NATURE PUBLISHING GROUP, 2019)
      RIPK1 regulates cell death and inflammation through kinase-dependent and -independent mechanisms. As a scaffold, RIPK1 inhibits caspase-8-dependent apoptosis and RIPK3/MLKL-dependent necroptosis. As a kinase, RIPK1 ...
    • SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells 

      Krabbendam, Inge E.; Honrath, Birgit; Bothof, Laura; Silva-Pavez, Eduardo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Huerta, Hernán [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Penaranda Fajardo, Natalia M.; Dekker, Frank; Schmidt, Martina; Culmsee, Carsten; Cardenas, César Julio [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Kruyt, Frank; Dolga, Amalia M. (Elsevier Inc., 2020-01)
      Brain tumours are among the deadliest tumours being highly resistant to currently available therapies. The proliferative behaviour of gliomas is strongly influenced by ion channel activity. Small-conductance calcium-activated ...
    • Teased Fiber Preparation of Myelinated Nerve Fibers from Peripheral Nerves for Vital Dye Staining and Immunofluorescence Analysis 

      Catenaccio, Alejandra [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (Humana Press, 2018)
      Glial cells regulate a wide variety of neuronal functions during physiological and pathological conditions. Therefore, the study of glial cells and their association with axons is of paramount importance in order to ...
    • The Enigmatic Role of C9ORF72 in Autophagy 

      Nassif, Melissa [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Woehlbier, Ute [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Manque, Patricio A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] (FRONTIERS MEDIA SA, 2017-08-03)
      Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the loss of motor neurons resulting in a progressive and irreversible muscular paralysis. Advances in large-scale genetics and ...


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