Listar Centro de Biología Integrativa (CBI) por título
Mostrando ítems 57-76 de 88
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Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
(BMC, 2019)BackgroundAmyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. ... -
Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction
(Nature Publishing Group, 2023-05-24)Gene-environment interactions are believed to play a role in multifactorial phenotypes, although poorly described mechanistically. Cleft lip/palate (CLP), the most common craniofacial malformation, has been associated with ... -
Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease
(Frontiers Media S.A., 2020-08)Nicotinamide (vitamin B3) is a key component in the cellular production of Nicotinamide Adenine Dinucleotide (NAD) and has long been associated with neuronal development, survival and death. Numerous data suggest that ... -
On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson's and Huntington's Disease
(Frontiers Media S.A., 2020-09)Movement disorders are neurological conditions in which patients manifest a diverse range of movement impairments. Distinct structures within the basal ganglia of the brain, an area involved in movement regulation, are ... -
Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium?
(CIENCIAS, 2016)The structural homeostasis is challenging for neurons, whose axons extend up to meters in large animals, and the axoplasmic mass reaches over a thousand times that of the cell body. Thus, the protein demand may overcome ... -
Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease
(FRONTIERS MEDIA SA, 2018)Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central ... -
P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis
(Nature Publishing Group, 2020-09)P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF ... -
Pangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts
(NATURE PORTFOLIO, 2021-02-09)Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which ... -
Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells
(Frontiers Media S.A., 2020-07)Endothelin-converting enzyme-1 (ECE1) activates the endothelin-1 peptide, which upregulates pathways that are related to diverse hallmarks of cancer. ECE1 is expressed as four isoforms differing in their N-terminal domains. ... -
Poly(ethylene imine)-chitosan carbon dots: study of its physical-chemical properties and biological in vitro performance
(Springer New York, 2023-10-17)Carbon dots (CDs) have been quickly extended for nanomedicine uses because of their multiple applications, such as bioimaging, sensors, and drug delivery. However, the interest in increasing their photoluminescence properties ... -
Protein Kinase CK2 in Cancer Energetics
(Frontiers Media S.A., 2020-06)Protein kinase CK2 (formerly known as casein kinase 2) is abnormally elevated in many cancers. This may increase tumor aggressiveness through CK2-dependent phosphorylation of key proteins in several signaling pathways. In ... -
Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs
(Humana Press, 2018)Exosomes are small (30-150 nm) vesicles of endosomal origin secreted by most cell types. Exosomes contain proteins, lipids, and RNA species including microRNA, mRNA, rRNA, and long noncoding RNAs. The mechanisms associated ... -
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
(NATURE PUBLISHING GROUP, 2018-01)How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high ... -
La Ruta del Pensamiento: una mirada actual al cáncer en Chile
(Chile. Universidad Mayor, 2021-08-20)El Doctor en Ciencias Biológicas e investigador del Centro de Biología Integrativa de la Universidad Mayor, Erick Riquelme, aborda el proceso de los tumores, los principales tratamientos, los últimos hallazgos para futuros ... -
La Ruta del Pensamiento: ¿Qué sabemos de las enfermedades que afectan al cerebro?
(Chile. Universidad Mayor, 2021-07-28)René Vidal, Doctor en Ciencias y académico del Centro de Biología Integrativa U. Mayor, realizó el webinar “¿Qué sabemos de las enfermedades que afectan al cerebro?”, donde profundizó en su funcionamiento y qué ocurre ... -
Salmonella Type III Secretion Effector SrfJ: A Glucosylceramidase Affecting the Lipidome and the Transcriptome of Mammalian Host Cells
(MDPI, 2023-05-07)Type III secretion systems are found in many Gram-negative pathogens and symbionts of animals and plants. Salmonella enterica has two type III secretion systems associated with virulence, one involved in the invasion of ... -
Schwann cell and axon: An interlaced unit—From action potential to phenotype expression
(Facultad de Ciencias, 2016)Here we propose a model of a peripheral axon with a great deal of autonomy from its cell body-the autonomous axon-but with a substantial dependence on its ensheathing Schwann cell (SC), the axon-SC unit. We review evidence ... -
Schwann cell reprogramming into repair cells increases miRNA-21 expression in exosomes promoting axonal growth
(Company of Biologists Ltd, 2020-06)Functional recovery after peripheral nerve damage is dependent on the reprogramming of differentiated Schwann cells (dSCs) into repair Schwann cells (rSCs), which promotes axonal regeneration and tissue homeostasis. ... -
Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury
(Wiley-Blackwell, 2023-12-07)Following peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell (SC) reprogramming into a reparative phenotype, a process dependent upon c-Jun transcription factor activation. ... -
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
(NATURE PUBLISHING GROUP, 2019)RIPK1 regulates cell death and inflammation through kinase-dependent and -independent mechanisms. As a scaffold, RIPK1 inhibits caspase-8-dependent apoptosis and RIPK3/MLKL-dependent necroptosis. As a kinase, RIPK1 ...